Key result
Chronic kidney disease was associated with increased common carotid artery intima-media thickness compared to controls (0.76 vs 0.59), with renal function deterioration directly affecting IMT (P=0.022).
Cross-Sectional (n=130)
Effect estimate: R2 = 0.208
Absolute Event Rate: 0.76% vs 0.59%
p-value: p=0.022
Mild renal dysfunction is associated with increased common carotid artery intima-media thickness, suggesting that CKD is an independent vascular risk factor.
CKD may flag higher subclinical atherosclerosis; leaves open whether IMT monitoring or intervention alters outcomes in mild disease.
AIM: Previous studies showed that patients with chronic kidney disease (CKD) > 2 dergee had increased intima-media thickness (IMT). We evaluate the relationship between IMT and parameters for renal function. METHODS: 130 subjects were examined - 66 with CKD, 44 without CKD, as well as 20 healthy volunteers. The first group- patients with CKD were with creatinine clearance (CrCl) over 20 ml/min and below 90 ml/min. The second group included 44 pts. with normal renal function, CrCl > 90 ml/min. All examined patients with and without CKD had hypertension. The two groups were streamed into two subgroups: with and without vascular disease. To evaluate the renal function creatinine clearance was calculated in ml/min. IMT was measured in both common carotid artery (CCA) using high resolution sonography in all examined subjects. RESULTS: CCA IMT increased in pts. with CKD and was > 0.75 ( 0.76 ± 0.14 v.s contols 0.59 ± 0.10) Patients with vascular disease (VD) had higher IMT which increased significant when CKD with GFR < 90 ml/min was included (0.77 ± 0.06/0.81 ± 0.10, p < 0.05). Multiple regression analysis proved that renal function deterioration directly affected CCA IMT (R 2 =0.208, p=0.022). CONCLUSION: Increased IMT is presented in mild renal dysfunction. CKD -GFR< 90 ml/min could be an independent vascular risk factor.
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Lubomirova et al. (2014) conducted a cross-sectional in Chronic kidney disease and hypertension (n=130). Chronic kidney disease vs. Normal renal function and healthy volunteers was evaluated on Common carotid artery intima-media thickness (CCA IMT) (R2 = 0.208, p=0.022). Chronic kidney disease was associated with increased common carotid artery intima-media thickness compared to controls (0.76 vs 0.59), with renal function deterioration directly affecting IMT (P=0.022).
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