Key result
IL3 combined with thrombopoietin promoted the survival of X-irradiated CD34+ megakaryocytic progenitor cells, showing marked shoulders on survival curves (D0 = 91 cGy, n = 2.83).
Population
X-irradiated CD34 megakaryocytic progenitor cells purified from normal human peripheral blood
Comparison
Combinations of thrombopoietin and cytokines vs Thrombopoietin alone
Design
Preclinical
Authors
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May guide cytokine radioprotection strategies; leaves open in vivo efficacy and clinical translation.
IL3 plays a key role in promoting the survival of X-irradiated CD34+ megakaryocytic progenitor cells from human peripheral blood.
Kashiwakura et al. (2002) studied X-irradiated CD34+ megakaryocytic progenitor cells. Thrombopoietin combined with cytokines (including IL3) vs. Thrombopoietin alone was evaluated on Radiation survival curves (D0 and extrapolation number n). IL3 combined with thrombopoietin promoted the survival of X-irradiated CD34+ megakaryocytic progenitor cells, showing marked shoulders on survival curves (D0 = 91 cGy, n = 2.83).
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