Key result
Higher levels of urinary DEHP metabolites MEHHP and MEOHP were significantly associated with decreased heart rate variability (lower TINN, VLF, and LF/HF ratio) in 974 young adults.
Why the study?
Phthalate exposure is linked to cardiovascular risk, but the association between exposure to the deleterious plasticizer di-(2-ethylhexyl) phthalate and alteration of heart rate variability required investigation.
Is exposure to DEHP associated with altered heart rate variability in young adults?
Cross-Sectional (n=974)
Is exposure to DEHP associated with altered heart rate variability in young adults?
Environmental exposure to the plasticizer DEHP is associated with decreased heart rate variability, suggesting an adverse effect on autonomic balance in young adults.
May link DEHP exposure to reduced HRV in young adults; hypothesis-generating and requires prospective studies before clinical relevance.
Phthalate exposure is associated with cardiovascular risk. Among the various phthalates, di-(2-ethylhexyl) phthalate (DEHP) is a deleterious plasticizer in our daily lives. This study investigated the association between DEHP exposure and the alteration of heart rate variability (HRV). During 2017-2019, we recruited 974 young adults to investigate the effects of living environments and dietary habits on cardiometabolic disorders in Taiwan. We quantitatively analyzed urinary metabolites of DHEP. A continuous electrocardiogram was recorded to obtain a 5-min ECG. Time-domain and frequency-domain HRV analyses were performed. Multiple linear regression showed that urinary oxidized DEHP metabolites MEHHP and MEOHP were associated with decreased HRV after controlling for associated cardiovascular risk factors. A higher MEHHP level was associated with a lower triangular interpolation of NN interval histogram (TINN), very low frequency (VLF), and low frequency/high frequency (LF/HF) ratio. A higher MEOHP level was associated with a decreased LF/HF ratio. In addition, trend analysis showed that higher MEHHP and MEOHP quantiles were significantly associated with a decreased LF/HF ratio. DEHP is a potentially harmful and invisible chemical. The urinary DEHP metabolites MEHHP and MEOHP are associated with decreased HRV, indicating an adverse effect on autonomic balance in young adults in Taiwan.
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Chen et al. (2021) conducted a cross-sectional in Heart rate variability alteration (n=974). Urinary DEHP metabolites (MEHHP and MEOHP) vs. Lower levels of DEHP metabolites was evaluated on Heart rate variability (HRV) including TINN, VLF, and LF/HF ratio. Higher levels of urinary DEHP metabolites MEHHP and MEOHP were significantly associated with decreased heart rate variability (lower TINN, VLF, and LF/HF ratio) in 974 young adults.
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