Key result
Nonviral systems for nucleic acid delivery using polymeric and inorganic vectors offer potential advantages over viral vectors, including reduced toxicity and immunogenicity, despite lower efficiency.
This review highlights the potential and challenges of polymeric and inorganic vectors for nonviral nucleic acid delivery, providing an overview of current materials and clinical trials.
Nonviral vectors merit exploration to reduce toxicity in nucleic acid therapies; leaves open efficiency optimization before clinical adoption.
Nonviral systems for nucleic acid delivery offer a host of potential advantages compared with viruses, including reduced toxicity and immunogenicity, increased ease of production and less stringent vector size limitations, but remain far less efficient than their viral counterparts. In this article we review recent advances in the delivery of nucleic acids using polymeric and inorganic vectors. We discuss the wide range of materials being designed and evaluated for these purposes while considering the physical requirements and barriers to entry that these agents face and reviewing recent novel approaches towards improving delivery with respect to each of these barriers. Furthermore, we provide a brief overview of past and ongoing nonviral gene therapy clinical trials. We conclude with a discussion of multifunctional nucleic acid carriers and future directions.
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Sunshine et al. (2011) conducted a review in Nucleic acid delivery. Polymeric and inorganic vectors vs. Viral vectors was evaluated. Nonviral systems for nucleic acid delivery using polymeric and inorganic vectors offer potential advantages over viral vectors, including reduced toxicity and immunogenicity, despite lower efficiency.
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