Key result
Intraduodenal gluten challenge induced pronounced mucosal changes characteristic of an Arthus-type reaction within a few hours in two treated coeliac subjects, but not in a healthy volunteer.
Why the study?
Does a single intraduodenal challenge with gluten fraction B induce histological damage in treated coeliac subjects?
Does a single intraduodenal challenge with gluten fraction B induce histological damage in treated coeliac subjects?
A single intraduodenal gluten challenge in treated coeliac patients rapidly induces mucosal changes characteristic of an Arthus-type reaction.
Should not alter coeliac management; hypothesis-generating for Arthus-type mucosal reactions and requires confirmation.
Two treated subjects and one healthy volunteer have been challenged with a single dose of fraction B of gluten administered intraduodenally. Serial biopsy specimens were obtained by means of a Quinton hydraulically operated biopsy instrument immediately before challenge and repeatedly thereafter. The biopsy specimens were studied by light microscopy, electron microscopy, immunofluorescence, immunoperoxidase staining and disaccharidase assay. The two coeliac subjects showed pronounced mucosal changes which developed a few hours after challenge and which showed the features of an Arthus-type reaction. The healthy volunteer was unaffected. It is concluded that the lesion of coeliac disease is the result of an Arthus-type reaction induced by ingested gluten in susceptible subjects.
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Anand et al. (1981) studied Coeliac disease (n=3). Fraction B of gluten vs. Healthy volunteer was evaluated on Mucosal changes. Intraduodenal gluten challenge induced pronounced mucosal changes characteristic of an Arthus-type reaction within a few hours in two treated coeliac subjects, but not in a healthy volunteer.
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