Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 3, 2013Alimentary Pharmacology & TherapeuticsOpen Access

Young adults with coeliac disease may be at increased risk of early atherosclerosis

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does a gluten-free diet improve instrumental and biochemical signs of atherosclerosis risk in adults with newly diagnosed coeliac disease?

Population

20 adults at first diagnosis of coeliac disease and 22 healthy matched controls (hospital staff)

Comparison

Gluten-free diet for 6-8 months with mucosal… vs Baseline measurements and healthy matched controls

Design

Cohort

Follow-up

6-8 months

Authors

SMSergio De MarchiGCGiuseppe ChiarioniMPManlio Prior

Discussion

Loading...

Member takes

Overview

Gluten-free diet was associated with improved lipid ratios, CRP, and vascular markers in coeliac disease; leaves open whether it reduces clinical cardiovascular events.

Structured PICO

Does a gluten-free diet improve instrumental and biochemical signs of atherosclerosis risk in adults with newly diagnosed coeliac disease?

P
Population
20 adults at first diagnosis of coeliac disease and 22 healthy matched controls (hospital staff)
I
Intervention
Gluten-free diet for 6-8 months with mucosal recovery
C
Comparator
Baseline measurements (pre-diet) and healthy matched controls
O
Outcome
Instrumental (carotid intima-media thickness and endothelium-dependent dilatation) and biochemical signs of atherosclerosis risksurrogate

Adults with newly diagnosed coeliac disease exhibit early signs of atherosclerosis and systemic inflammation, which are reversible with a gluten-free diet.

Cite This Study

Marchi et al. (2013) studied this question.

synapsesocial.com/papers/6a737ddd427d94f6ee71b046https://doi.org/10.1111/apt.12360
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Celiac Disease Associated With Autoimmune Myocarditis2002 · 189 citations
  2. 2Risk of cardiovascular disease measured by carotid intima-media thickness at age 49-51: lifecourse study2000 · 163 citations
  3. 3Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility.1995 · 697 citations
  4. 4Homocysteine and MTHFR Mutations2005 · 162 citations
  5. 5Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery2002 · 4,614 citations