Key result
Recent celiac disease diagnosis is linked to ~4-fold higher hs-CRP alongside worsened cardiometabolic markers.
Why the study?
This study aimed to evaluate novel risk factors and biomarkers of cardiovascular disease in recently diagnosed celiac disease patients compared with healthy controls.
Is recently diagnosed celiac disease associated with altered biomarkers of inflammation, insulin resistance, and lipoprotein metabolism compared with healthy controls?
Case-Control (n=40)
Is recently diagnosed celiac disease associated with altered biomarkers of inflammation, insulin resistance, and lipoprotein metabolism compared with healthy controls?
Answers are grounded in this paper and cite their sources.
Patients with recently diagnosed celiac disease exhibit elevated systemic inflammation, insulin resistance, and an atherogenic lipid profile that may increase their risk for atherosclerotic cardiovascular disease.
Aim To evaluate novel risk factors and biomarkers of cardiovascular disease in celiac disease (CD) patients compared with healthy controls. Methods Twenty adult patients with recent diagnosis of CD and 20 sex, age and body mass index-matched healthy controls were recruited during a period of 12 mo. Indicators of carbohydrate metabolism, hematological parameters and high sensitive C reactive protein were determined. Moreover, lipoprotein metabolism was also explored through evaluation of the lipid profile and the activity of cholesteryl ester transfer protein and lipoprotein associated phospholipase A2, which is also considered a specific marker of vascular inflammation. The protocol was approved by the Ethic Committee from School of Pharmacy and Biochemistry, University of Buenos Aires and from Buenos Aires Italian Hospital, Buenos Aires, Argentina. Results Regarding the indicators of insulin resistance, CD patients showed higher plasma insulin levels [7.2 (5.0-11.3) mU/L vs 4.6 (2.6-6.7) mU/L, P < 0.05], increased Homeostasis Model Assessment-Insulin Resistance [1.45 (1.04-2.24) vs 1.00 (0.51-1.45), P < 0.05] and lower Quantitative Sensitive Check index [0.33 (0.28-0.40) vs 0.42 (0.34-0.65), P < 0.05] indexes. Folic acid concentration [5.4 (4.4-7.9) ng/mL vs 12.2 (8.0-14.2) ng/mL, P < 0.01] resulted to be lower and High-sensitivity C reactive protein levels higher (4.21 ± 6.47 mg/L vs 0.98 ± 1.13 mg/L, P < 0.01) in the patient group. With respect to the lipoprotein profile, CD patients showed lower high density lipoprotein-cholesterol (HDL-C) (45 ± 15 mg/dL vs 57 ± 17 mg/dL, P < 0.05) and apo A-I (130 ± 31 mg/dL vs 155 ± 29 mg/dL, P < 0.05) levels, as well as higher total cholesterol/HDL-C [4.19 (3.11-5.00) vs 3.52 (2.84-4.08), P < 0.05] and apo B/apo A-I (0.75 ± 0.25 vs 0.55 ± 0.16, P < 0.05) ratios in comparison with control subjects. No statistically significant differences were detected in lipoprotein-associated lipid transfer protein and enzymes. Conclusion The presence and interaction of the detected alterations in patients with CD, would constitute a risk factor for the development of atherosclerotic cardiovascular disease.
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Tetzlaff et al. (2017) conducted a case-control in Recently diagnosed celiac disease (n=40). Recently diagnosed celiac disease vs. Sex, age, and body mass index-matched healthy controls was evaluated on High-sensitivity C-reactive protein (hs-CRP) levels (p=<0.01). Recently diagnosed celiac disease was associated with higher hs-CRP, higher HOMA-IR, and lower HDL-C vs controls.
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