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January 1, 2017World Journal of CardiologyOpen Access

Significant differences (p < 0.05) in certain biomarker ratios were found in celiac patients compared to controls, though no statistically significant differences were detected in lipoprotein-associated lipid transfer protein and enzymes.

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Why the study?

Are biomarkers of cardiovascular disease and inflammation altered in patients with recently diagnosed celiac disease compared to healthy controls?

Population

40 adults, comprising 20 patients with recently diagnosed celiac disease and 20 sex, age, and body mass…

Design

Case-control

Authors

WTWalter TetzlaffTMTomás MeroñoMMMartín Menafra

Discussion

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Overview

May indicate altered CV biomarkers in new CD; leaves open whether these affect risk or merit screening.

Structured PICO

Are biomarkers of cardiovascular disease and inflammation altered in patients with recently diagnosed celiac disease compared to healthy controls?

P
Population
40 adults, comprising 20 patients with recently diagnosed celiac disease and 20 sex, age, and body mass index-matched healthy controls.
C
Comparator
20 sex, age and body mass index-matched healthy controls
O
Outcome
Indicators of carbohydrate metabolism, hematological parameters, high sensitive C reactive protein, lipid profile, and activity of cholesteryl ester transfer protein and lipoprotein associated phospholipase A2surrogate

Patients with recently diagnosed celiac disease may exhibit alterations in inflammatory and cardiovascular biomarkers that could constitute a risk factor for atherosclerotic cardiovascular disease.

Cite This Study

Tetzlaff et al. (2017) studied this question.

synapsesocial.com/papers/6a7116a9439bab0cabc37266https://doi.org/10.4330/wjc.v9.i5.448
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Young adults with coeliac disease may be at increased risk of early atherosclerosis2013 · 84 citations
  2. 2Increased arterial stiffness and its relationship with inflammation, insulin, and insulin resistance in celiac disease2015 · 33 citations
  3. 3Atherosclerosis and cardiovascular involvement in celiac disease: the role of autoimmunity and inflammation.2017 · 31 citations
  4. 4HEART RATE VARIABILITY IS AFFECTED IN YOUNG ADULT CELIAC PATIENTS, INDICATING AUTONOMIC DYSFUNCTION AND INCREASED CARDIOVASCULAR RISK2022
  5. 5Beyond the Gut: Exploring Cardiovascular Implications of Celiac Disease2024