Key result
Epidural analgesia and ketamine-lidocaine co-analgesia significantly reduced postoperative pain intensity at 1 hour (median VAS 3 and 6, respectively, vs 8) compared to standard analgesia in major abdominal surgery.
Why the study?
Opioids have known side effects, motivating the investigation of adjuvant multimodal opioid-sparing analgesia techniques including ketamine, lidocaine, and epidural analgesia following major abdominal surgery.
Does multimodal analgesia (ketamine/lidocaine or epidural) reduce postoperative pain intensity in patients undergoing major abdominal surgery?
Population
80 patients undergoing major abdominal surgery
Comparison
Systemic ketamine and lidocaine vs epidural analgesia vs standard opioid-based analgesia
Design
Monocentric randomized clinical study
Follow-up
12 h postoperatively
Authors
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Supports multimodal analgesia to curb opioid use after major abdominal surgery; extends RCT evidence for ketamine/lidocaine and epidural regimens.
RCT (n=80)
Open-label
Urn randomization technique
No
Does multimodal analgesia (ketamine/lidocaine or epidural) reduce postoperative pain intensity in patients undergoing major abdominal surgery?
Absolute Event Rate: 3% vs 8%
p-value: p=<0.0001
Multimodal analgesia with ketamine/lidocaine or epidural analgesia effectively reduces postoperative pain and opioid requirements in major abdominal surgery.
Jipa et al. (2022) conducted an RCT in Major abdominal surgery (n=80). Ketamine-lidocaine co-analgesia or epidural analgesia vs. Standard analgesia (fentanyl, acetaminophen, metamizole) was evaluated on Visual analogue scale (VAS) score at 1 hour postoperatively (p=<0.0001). Epidural analgesia and ketamine-lidocaine co-analgesia significantly reduced postoperative pain intensity at 1 hour (median VAS 3 and 6, respectively, vs 8) compared to standard analgesia in major abdominal surgery.
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