Key result
Spontaneous electrical activity in guinea pig mesenteric arteries was myogenic in origin, driven by sympathetic nerve stimulation, and reversibly decreased by adenosine and lower temperatures.
Population
Smooth muscle cells of guinea pig small pressurized mesenteric arteries in vitro
Comparison
Application of tetrodotoxin, guanethidine… vs Baseline conditions
Design
Preclinical
Authors
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No immediate clinical implications; leaves open translation of adenosine- and temperature-sensitive myogenic activity to human vessels.
Spontaneous myogenic electrical activity in guinea pig mesenteric arteries is modulated by adenosine and temperature, suggesting a role in the physiological control of arterial tone.
Zelcer et al. (2008) studied this question. Adenosine, temperature changes, and sympathetic nerve stimulation was evaluated on Spontaneous electrical activity (action potential amplitude and frequency). Spontaneous electrical activity in guinea pig mesenteric arteries was myogenic in origin, driven by sympathetic nerve stimulation, and reversibly decreased by adenosine and lower temperatures.
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