Key result
Hypertrophic stimuli (mIGF-1 transgene or chronic exercise) increased muscle cross-sectional area in both singly and multiply innervated mouse gracilis muscles through different structural adaptations.
Population
Mouse gracilis muscles (anterior and posterior) in wild-type and myosin light chain/mIGF transgenic mice
Comparison
Expression of a muscle-specific insulin-like… vs Control mice (implied)
Design
Preclinical
Authors
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Mouse models reveal innervation-specific hypertrophy; leaves open whether patterns inform human neuromuscular disease modeling.
Different modes of skeletal muscle hypertrophy exist depending on innervation patterns, which has implications for modeling human neuromuscular diseases.
Paul et al. (2002) studied Muscle hypertrophy. Muscle-specific insulin-like growth factor (IGF)-1 transgene (mIGF-1) or chronic exercise was evaluated on Muscle cross-sectional area, fiber diameter, fiber length, and centralized nuclei. Hypertrophic stimuli (mIGF-1 transgene or chronic exercise) increased muscle cross-sectional area in both singly and multiply innervated mouse gracilis muscles through different structural adaptations.
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