Key result
Perioperative IV ketorolac in addition to opioids was associated with significantly lower mean pain intensity compared to no IV ketorolac (2.9 vs 3.7; P=.002) in pediatric patients after appendectomy.
Why the study?
Does perioperative IV ketorolac in addition to opioids reduce postoperative pain intensity in pediatric patients after laparoscopic appendectomy?
Observational (n=200)
Does perioperative IV ketorolac in addition to opioids reduce postoperative pain intensity in pediatric patients after laparoscopic appendectomy?
Absolute Event Rate: 2.9% vs 3.7%
p-value: p=.002
Perioperative IV ketorolac added to opioids significantly reduces postoperative pain intensity and opioid consumption in children following laparoscopic appendectomy.
May support adjunctive ketorolac for lower pain after pediatric appendectomy; leaves open confirmation in randomized trials.
Knowledge of the effectiveness of multimodal analgesic treatments to manage children's postoperative pain during hospital stays is limited. Our retrospective chart review of a convenience sample of 200 pediatric surgical patients' pain experiences during the first 24 hours after laparoscopic appendectomy demonstrates the benefits of a multimodal analgesic approach. We found that pediatric patients who received perioperative IV ketorolac in addition to opioids reported statistically significantly lower mean pain intensity (n = 134, mean [M] = 2.9, standard deviation [SD] = 1.7) during the first 24 hours after surgery when compared with the pain intensity of patients who did not receive perioperative IV ketorolac (n = 66, M = 3.7, SD = 1.7, t = 3.14, P = .002). Patients who received perioperative IV ketorolac (M = 0.94, SD = 0.71) also received significantly fewer morphine equivalents of postoperative opioids during the first 24 hours after surgery than those who did not (M = 1.21, SD = 0.78, t = 2.41, P = .02). We will use data from these patients to introduce the potential for a personalized medicine approach to postoperative pain.
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Manworren et al. (2016) conducted an observational in postoperative pain after laparoscopic appendectomy (n=200). perioperative IV ketorolac in addition to opioids vs. no perioperative IV ketorolac was evaluated on mean pain intensity during the first 24 hours after surgery (p=.002). Perioperative IV ketorolac in addition to opioids was associated with significantly lower mean pain intensity compared to no IV ketorolac (2.9 vs 3.7; P=.002) in pediatric patients after appendectomy.
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