What question did this study set out to answer?

To investigate the pathophysiological function of muscle-derived GDF15 in regulating systemic metabolic stress responses during mitochondrial dysfunction.

February 6, 2020EMBO ReportsOpen Access

Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress

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Authors

MOMario OstLeipzig University CGCarla Igual Gil VCVerena ColemanGerman Institute of Human Nutrition

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Implication

Transgenic mouse study reveals muscle-derived GDF15 drives daytime-restricted anorexia and metabolic adaptation, highlighting its role in systemic energy balance during mitochondrial stress.

Key Points

To investigate the pathophysiological function of muscle-derived GDF15 in regulating systemic metabolic stress responses during mitochondrial dysfunction.
Studied transgenic mice (Ucp1-TG) with compromised skeletal muscle mitochondrial OXPHOS capacity induced by respiratory uncoupling.
Generated and evaluated GDF15-deficient Ucp1-TG mice to assess effects on muscle wasting, body composition, systemic metabolism, and feeding rhythms.
Ucp1-TG mice exhibited skeletal muscle-specific induction and diurnal variation of GDF15, which triggered daytime-restricted anorexia without altering nocturnal food intake.
Genetic ablation of GDF15 in Ucp1-TG mice did not modify muscle wasting or cell-autonomous transcriptional stress responses, but led to a progressive increase in body fat mass.
Loss of GDF15 completely abolished muscle mitochondrial stress-induced systemic metabolic flexibility, improved insulin sensitivity, and white adipose tissue browning.

Cite This Study

Ost et al. (2020) studied this question.

synapsesocial.com/papers/6a93d158cd4df3c00e006824 https://doi.org/10.15252/embr.201948804

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Implication

Transgenic mouse study reveals muscle-derived GDF15 drives daytime-restricted anorexia and metabolic adaptation, highlighting its role in systemic energy balance during mitochondrial stress.

Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress

Discussion

Member takes

Implication

Key Points

Cite This Study

Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress

Discussion

Member takes

Implication

Key Points

Cite This Study

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