In 13 fasting men with and without duodenal ulcer, oral administration of 2 g of calcium carbonate produced a significant increase (p<0.025) in gastric acid secretion above basal levels for two hours. Serum gastrin concentration increased significantly (p<0.05) 30 and 60 minutes after administration of 2 g of calcium carbonate. No significant change in acid secretion or serum gastrin occurred after oral administration of 2 g of sodium bicarbonate. In additional tests, a significant increase (p<0.05) in acid secretion occurred in each of five subjects given 0.5 g of calcium carbonate by mouth. Single oral doses of calcium carbonate thus appear capable of stimulating gastric acid secretion and gastrin release in fasting subjects with and without duodenal ulcer. (N Engl J Med 289:555–558, 1973)
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Levant et al. (1973) studied this question.
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