Key result
Hypercalcemia secondary to milk-alkali syndrome was reported as the cause of second- and third-degree A-V block in a 38-year-old man.
Case Report (n=1)
This case report highlights that severe hypercalcemia, such as from milk-alkali syndrome, can be a rare cause of second- and third-degree atrioventricular block.
Answers are grounded in this paper and cite their sources.
May prompt calcium check in unexplained AV block; single case leaves open broader screening or causality.
Letters1 December 1973Hypercalcemia and Complete Heart BlockHENRY GINSBERG, M.D., KENNETH V. SCHWARTZ, M.D.HENRY GINSBERG, M.D., KENNETH V. SCHWARTZ, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-6-903_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The presence of complete atrioventricular (A-V) block in an acutely ill patient is most often associated with an acute myocardial infarction. Less common causes are bacterial endocarditis, inflammatory lesions of the conduction system, and thyrotoxicosis. We report a case in which hypercalcemia secondary to the milk-alkali syndrome (1, 2) seemed to be the cause of complete A-V block. Although first-degree heart block has been reported in association with hypercalcemia (3), we believe that this is the first reported case in which second- and third-degree A-V block developed secondary to hypercalcemia.A 38-year-old man presented with a 2-day...References1. MCMILLAN D and FREEMAN R: Milk-alkali syndrome: a study of the acute disorder with comments on the development of the chronic condition. Medicine (Baltimore) 44:485-501, 1965 CrossrefMedlineGoogle Scholar2. PUNSAR S and SOME T: The milk-alkali syndrome. Acta Med Scand 173:435-449, 1963 CrossrefMedlineGoogle Scholar3. BRONSKY D, DUBIN A, and WALDSTEIN S: Calcium and the electrocardiogram. II. the electrocardiographic manifestations of hyperparathyroidism and of marked hypercalcemia from various other etiologies. Am J Cardiol 7:833-839, 1961 CrossrefGoogle Scholar4. HOFF H, SMITH P, and WINKLER A: Electrocardiographic changes and concentration of calcium in serum following injection of calcium chloride. Am J Physiol 125:162-171, 1939 CrossrefGoogle Scholar5. CLARKE H: The action of calcium on the human electrocardiogram. Am Heart J 22:367-373, 1941 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HENRY GINSBERG, M.D.; KENNETH V. SCHWARTZ, M.D.Affiliations: Boston University Medical Services Boston City Hospital Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComplete heart block associated with paraneoplastic hypercalcemia: a case reportReversible complete heart block due to hypercalcaemiaEnvironmental Toxins and the HeartCardiac conduction in patients with hypercalcaemia due to primary hyperparathyroidismExtranodal renal non-Hodgkin's lymphoma and severe hypercalcaemiaPractical aspects of advanced paediatric cardiopulmonary resuscitationEnhancement by Ca2+ ions of cholinergic effects on the canine heart in situTreatment of HypercalcemiaCase 40-1974 1 December 1973Volume 79, Issue 6Page: 903-903KeywordsAcute myocardial infarctionEndocarditisHeartHypercalcemiaLesions ePublished: 1 December 2008 Issue Published: 1 December 1973 PDF downloadLoading ...
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Henry N. Ginsberg (1973) conducted a case report in Hypercalcemia and Complete Heart Block (n=1). Hypercalcemia (milk-alkali syndrome) was evaluated on Complete A-V block. Hypercalcemia secondary to milk-alkali syndrome was reported as the cause of second- and third-degree A-V block in a 38-year-old man.
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