Key result
Electrocardiographic left ventricular hypertrophy was associated with a significantly higher risk of major cardiovascular events compared to patients without ECG-LVH (19.0% vs 15.6%; P=0.0023).
Why the study?
Does the presence of ECG-LVH predict mortality and cardiovascular morbidity in high-risk patients with established cardiovascular diseases?
Population
9,541 men and women aged 55 years or older with a history of coronary artery disease, stroke, peripheral…
Comparison
Presence of left ventricular hypertrophy… vs Absence of ECG-LVH
Design
Cohort
Follow-up
average 4.5 years
Authors
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ECG-LVH identifies higher MACE risk in established CVD; supports risk stratification yet leaves open whether targeted therapy improves outcomes.
RCT (n=9,541)
randomized
Does the presence of ECG-LVH predict mortality and cardiovascular morbidity in high-risk patients with established cardiovascular diseases?
Absolute Event Rate: 19% vs 15.6%
p-value: p=0.0023
Simple ECG criteria for LVH independently predict cardiovascular death, all-cause mortality, and heart failure in high-risk patients with established cardiovascular disease.
Lonn et al. (2003) conducted an RCT in Cardiovascular disease or diabetes with additional risk factor (n=9,541). Electrocardiographic left ventricular hypertrophy (ECG-LVH) vs. Without ECG-LVH was evaluated on Major CV event (MI, stroke or CV death) (p=0.0023). Electrocardiographic left ventricular hypertrophy was associated with a significantly higher risk of major cardiovascular events compared to patients without ECG-LVH (19.0% vs 15.6%; P=0.0023).
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