Effect of Teasing and Sham Feeding on Plasma Glucagon Concentration in Dogs

Plasma glucagon concentration was determined by radioimmunoassay during fasting and following teasing and sham feeding. Teasing and sham feeding for 1--10 min raised the plasma glucagon concentration which then within a short period of time returned to the basal level. Atropinization (0.2 mg/kg) almost abolished the glucagon response to 10 min of sham feeding. Glucose concentration was slightly elevated in response to 10 min of sham feeding. The results show that physiological stimulation that is induced by the smell, sight and taste of food releases glucagon in the dog. The release is mediated by a cholinergic mechanism.