Key result
Electrospun scaffolds made from a resorbable supramolecular elastomer showed no consistent collagen organization in the predefined direction after 12 months of implantation in sheep.
Why the study?
In situ tissue engineering using resorbable synthetic heart valve scaffolds is an affordable and practical approach for heart valve replacement attractive for clinical use.
Does the architecture of resorbable synthetic heart valve scaffolds determine collagen organization after 12 months of implantation in sheep?
Population
Sheep
Comparison
Resorbable supramolecular elastomer electrospun scaffolds with random vs circumferentially aligned fibers
Design
Preclinical animal study
Follow-up
12 months
Authors
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Challenges assumptions on fiber alignment for directed remodeling in valve scaffolds; leaves open further preclinical optimization before translation.
Does the architecture of resorbable synthetic heart valve scaffolds determine collagen organization after 12 months of implantation in sheep?
In situ remodeling processes override the initial scaffold architecture in tissue-engineered heart valves, indicating a need for deeper mechanistic understanding before clinical application.
Uiterwijk et al. (2020) studied Heart valve replacement. Electrospun scaffolds made from a resorbable supramolecular elastomer was evaluated on Collagen organization in the predefined direction. Electrospun scaffolds made from a resorbable supramolecular elastomer showed no consistent collagen organization in the predefined direction after 12 months of implantation in sheep.
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