Key result
Pulmonary valve replacement with a biological valve showed excellent mid-term results at 5 years, with 3 new valve replacements and 5 total deaths among 90 patients.
Why the study?
Does pulmonary valve replacement with a bovine pericardial valve improve hemodynamics and exercise capacity in patients with congenital heart disease?
Cross-Sectional (n=90)
Does pulmonary valve replacement with a bovine pericardial valve improve hemodynamics and exercise capacity in patients with congenital heart disease?
Bovine pericardial valves in the pulmonary position show excellent mid-term results with low gradients, mild to moderate insufficiency, and improved oxygen uptake at 5 years.
May support biological pulmonary valve replacement in congenital disease; extends observational data but leaves randomized confirmation open.
OBJECTIVES: From a population of 90 patients after pulmonary valve replacement with a biological valve (Carpentier-Edwards Perimount valve), 56 of 80 available patients were examined five years after surgery. BACKGROUND: Pulmonary valve replacement is needed in many patients with congenital heart disease. Homografts have limited availability and predictable degeneration, and mechanical valves require anticoagulation. No superiority of one kind of pulmonary valve replacement has been shown. Biological valves that are readily available are being used and evaluated in increasing numbers. METHODS: In this cross-sectional study, five years following surgery, data were gathered from hospital charts, echocardiography, stress echocardiography, magnetic resonance imaging, and exercise testing. RESULTS: In 90 patients, there were three new valve replacements, one early cardiac death, and four late noncardiac deaths. Echocardiographic assessment of the study group showed pulmonary Doppler velocities (m/s) before, after operation, and at five-year follow-up of 2.8±1.1, 1.6±0.4, and 2.3±0.7, respectively. The assessed insufficiencies (0-3) at the same times were 2.3±1.0, 0.3±0.4, and 1.1±0.8. Maximal oxygen uptake increased from 65.6%±10.1% to 77.1%±18.2% of predicted and QRS width increased by 7±23 ms. Valve degeneration could be associated with young age but not with diagnosis or valve size. CONCLUSION: In our study, the biological valve in the pulmonary position showed excellent mid-term results with few reoperations, low gradients, and mild to moderate insufficiency. Oversizing, in contrast to young age, was not a risk factor for valve degeneration. In younger patients, this allows later percutaneous replacement, reducing the need for further surgery. However, longer follow-up is needed.
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Neukamm et al. (2014) conducted a cross-sectional in Congenital heart disease (n=90). Pulmonary valve replacement with a biological valve (Carpentier-Edwards Perimount valve) was evaluated on Clinical and echocardiographic outcomes at 5 years. Pulmonary valve replacement with a biological valve showed excellent mid-term results at 5 years, with 3 new valve replacements and 5 total deaths among 90 patients.
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