Long-term outcome after right ventricle to pulmonary artery conduit surgery and reintervention
Key result
Ten-year reintervention-free survival was significantly lower after the first conduit reintervention compared to the first conduit operation (70% vs 77%, p=0.04).
Why the study?
What are the long-term survival and reintervention rates after right ventricle to pulmonary artery conduit surgery in adult patients with congenital heart disease?
Population
574 adult patients with a right ventricle to pulmonary artery conduit identified in the Swedish National…
Design
Cohort
Follow-up
up to 48 years
Authors
Discussion
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Member takes
Implication
Inferior durability after reintervention may affect timing decisions; leaves open prospective evaluation of conduit options.
Study Design
Type
Cohort (n=574)
Multicenter
Yes
Structured PICO
What are the long-term survival and reintervention rates after right ventricle to pulmonary artery conduit surgery in adult patients with congenital heart disease?
P
Population
574 adult patients (mean age 36.1 years) with a right ventricle to pulmonary artery conduit who survived to at least 16 years of age, followed for up to 48 years.
E
Exposure
Right ventricle to pulmonary artery conduit surgery and subsequent reinterventions (including transcatheter pulmonary valve replacement)
O
Outcome
Long-term survival and reintervention-free survivalhard clinical
Main Result
Absolute Event Rate: 70% vs 77%
p-value: p=0.04
In adult survivors of right ventricle to pulmonary artery conduit surgery, long-term survival is excellent, but the need for reintervention is considerable and occurs earlier after subsequent reinterventions.
Limitations
- Data on patients who died before age of 16 years are not included in the registry and thus not included in the study.
- Findings only apply to patients reaching 16 years of age (survivorship bias)
Cite This Study
Skoglund et al. (2017) conducted a cohort in Congenital heart disease with right ventricle to pulmonary artery conduit (n=574). First conduit reintervention vs. First conduit operation was evaluated on 10-year reintervention-free survival (p=0.04). Ten-year reintervention-free survival was significantly lower after the first conduit reintervention compared to the first conduit operation (70% vs 77%, p=0.04).