Key result
High peri-surgical opioid exposure was associated with increased odds of persistent opioid use at 30 days (OR 1.38; 95% CI 1.24-1.54) and 90 days post-discharge compared to low exposure.
Why the study?
A knowledge gap exists regarding the association between peri-surgical opioid exposure levels and post-discharge adverse outcomes to patients and healthcare settings.
Does high peri-surgical opioid exposure increase persistent opioid use and adverse outcomes in surgical patients?
Population
Patients undergoing cesarean delivery, hysterectomy, spine surgery, total hip arthroplasty, or total knee arthroplasty
Comparison
High peri-surgical opioid exposure vs low peri-surgical opioid exposure
Design
Retrospective cohort study
Follow-up
180 days
Authors
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May support minimizing peri-surgical opioids; leaves open causal confirmation in randomized trials.
Cohort
No
Does high peri-surgical opioid exposure increase persistent opioid use and adverse outcomes in surgical patients?
Odds Ratio: 1.38 (95% CI 1.24–1.54)
Higher peri-surgical opioid exposure is significantly associated with increased odds of persistent opioid use and greater healthcare resource utilization post-discharge.
Kim et al. (2022) conducted a cohort in Post-surgical patients. High peri-surgical opioid exposure (>median MME) vs. Low peri-surgical opioid exposure (≤median MME) was evaluated on Persistent opioid use 30 days after discharge (OR 1.38, 95% CI 1.24-1.54). High peri-surgical opioid exposure was associated with increased odds of persistent opioid use at 30 days (OR 1.38; 95% CI 1.24-1.54) and 90 days post-discharge compared to low exposure.
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