Key result
Alcohol ingestion in two patients with alcohol-induced variant angina led to elevated plasma endothelin-1 concentrations (4.09 and 4.36 pg/ml) 5 hours post-ingestion, which normalized after abstinence.
Why the study?
Does alcohol ingestion increase plasma endothelin-1 levels in patients with alcohol-induced variant angina?
Case Report (n=11)
No
Does alcohol ingestion increase plasma endothelin-1 levels in patients with alcohol-induced variant angina?
Alcohol-induced variant angina may be mediated by elevations in plasma endothelin-1 concentrations following alcohol ingestion.
May implicate endothelin-1 in alcohol-induced variant angina; leaves open causal confirmation beyond case reports.
Vasospastic angina as a result of alcohol ingestion has been reported, but the mechanism of alcohol-induced coronary artery spasm is presently unknown. This report presents 2 cases of alcohol-induced variant angina (VA) with elevated levels of plasma endothelin-1 after alcohol ingestion. In case 1, the plasma endothelin-1 concentration was 3.15 pg/ml before drinking (normal <2.30 pg/ml) and increased to 4.09 pg/ml when measured 5 h after alcohol ingestion. After 2 months of abstinence, the plasma endothelin-1 concentration was 2.88 pg/ml and 6 months after abstinence, it decreased to 2.03 pg/ml (normal range). In case 2, the plasma endothelin-1 concentration was 2.44 pg/ml before drinking and increased to 4.36 pg/ml when measured 5 h after alcohol ingestion. After 2 months of abstinence, the plasma endothelin-1 concentration was 3.04 pg/ml and 6 months after abstinence, it decreased to 2.09 pg/ml (normal range). These 2 cases suggest that a relationship may exist between alcohol-induced VA and elevation in the plasma endothelin-1 concentration after alcohol ingestion.
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Kaku et al. (1999) conducted a case report in Alcohol-induced variant angina (n=11). Alcohol ingestion vs. Baseline (prior to alcohol ingestion) was evaluated on Plasma endothelin-1 concentration 5 hours after alcohol ingestion. Alcohol ingestion in two patients with alcohol-induced variant angina led to elevated plasma endothelin-1 concentrations (4.09 and 4.36 pg/ml) 5 hours post-ingestion, which normalized after abstinence.
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