Key result
Among asymptomatic patients with end-stage renal disease receiving hemodialysis, none had falsely elevated cardiac troponin I levels >0.8 ng/dL.
Why the study?
Are cardiac troponin I levels falsely elevated in asymptomatic patients with end-stage renal disease receiving hemodialysis?
Cohort
No
Are cardiac troponin I levels falsely elevated in asymptomatic patients with end-stage renal disease receiving hemodialysis?
Cardiac troponin I levels are not falsely elevated in asymptomatic ESRD patients on hemodialysis, indicating that elevated levels (>0.8 ng/dL) likely reflect true myocardial injury.
Answers are grounded in this paper and cite their sources.
Supports interpreting troponin I >0.8 ng/dL as true injury in asymptomatic ESRD on hemodialysis; leaves open confirmation in larger cohorts.
OBJECTIVES: Patients with end-stage renal disease (ESRD) who are receiving hemodialysis have an increased incidence of atherosclerotic heart disease. Currently, there is considerable controversy regarding the significance of elevated cardiac troponin I (cTnI) levels in patients with ESRD. The objective of this study was to examine the prevalence of elevated cTnI levels in asymptomatic patients with ESRD on hemodialysis. METHODS: This was a prospective cohort study at an urban hospital outpatient dialysis center. Serum was collected pre- and postdialysis from patients on dialysis at this center over a two-week period. Samples were batched and analyzed for cTnI using the Asxym fluorescent antibody test. An elevated cTnI level was defined as >0.8 ng/dL. RESULTS: Predialysis cTnI levels ranged from <0.1 to 0.7 ng/dL, and postdialysis cTnI levels ranged from <0.1 to 0.6 ng/dL. None of the patients had a cTnI level >0.8 ng/dL. CONCLUSIONS: cTnI levels are not falsely elevated in patients with ESRD on hemodialysis. In a patient with ESRD, myocardial injury should be suspected if his or her cTnI level is >0.8 ng/dL.
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Donnino et al. (2004) conducted a cohort in End-stage renal disease (ESRD). Hemodialysis was evaluated on Elevated cardiac troponin I (cTnI) level (>0.8 ng/dL). Among asymptomatic patients with end-stage renal disease receiving hemodialysis, none had falsely elevated cardiac troponin I levels >0.8 ng/dL.
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