Key result
Adults with obstructive sleep apnea (n=27) exhibited decreased prefrontal connection edge numbers and lower network efficiency compared to healthy controls (n=25).
Why the study?
To assess prefrontal brain network abnormality in adults with obstructive sleep apnea using resting-state functional near infrared spectroscopy.
Does resting-state functional near infrared spectroscopy (rs-fNIRS) identify prefrontal brain network abnormalities in adults with obstructive sleep apnea compared to healthy controls?
Observational (n=52)
Does resting-state functional near infrared spectroscopy (rs-fNIRS) identify prefrontal brain network abnormalities in adults with obstructive sleep apnea compared to healthy controls?
Prefrontal rs-fNIRS identifies decreased functional connectivity and network efficiency in adults with OSA, which correlates with cognitive impairment.
Prefrontal network alterations in OSA remain hypothesis-generating; larger studies needed before clinical relevance.
To assess prefrontal brain network abnormality in adults with obstructive sleep apnea (OSA), resting-state functional near infrared spectroscopy (rs-fNIRS) was used to evaluate 52 subjects, including 27 with OSA and 25 healthy controls (HC). The study found that patients with OSA had a decreased connection edge number, particularly in the connection between the right medial frontal cortex (MFG-R) and other right-hemisphere regions. Graph-based analysis also revealed that patients with OSA had a lower global efficiency, local efficiency, and clustering coefficient than the HC group. Additionally, the study found a significant positive correlation between the Montreal Cognitive Assessment (MoCA) score and both the connection edge number and the graph-based indicators in patients with OSA. These preliminary results suggest that prefrontal rs-fNIRS could be a useful tool for objectively and quantitatively assessing cognitive function impairment in patients with OSA.
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Chen et al. (2023) conducted an observational in Obstructive sleep apnea (n=52). Obstructive sleep apnea vs. Healthy controls was evaluated on Prefrontal brain network abnormality (connection edge number and graph-based indicators). Adults with obstructive sleep apnea (n=27) exhibited decreased prefrontal connection edge numbers and lower network efficiency compared to healthy controls (n=25).
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