Key result
A baseline HADS-D score >5 points was significantly associated with an increased risk of all-cause mortality and heart failure hospitalisation (adjusted HR 2.17; 95% CI 1.05 to 4.48; p=0.036).
Why the study?
Depressive symptoms frequently occur in heart failure, but research evaluating their relationship with NT-proBNP is scarce and inconsistent.
Does a HADS-D score > 5 points increase the risk of all-cause mortality and HF hospitalisation in patients with heart failure?
Cohort (n=151)
Does a HADS-D score > 5 points increase the risk of all-cause mortality and HF hospitalisation in patients with heart failure?
Hazard Ratio: 2.17 (95% CI 1.05–4.48)
p-value: p=0.036
Depressive symptoms in heart failure patients correlate with higher NT-proBNP levels, worse health status, and a doubled risk of mortality or HF hospitalization.
Depressive symptoms may flag higher-risk HF patients; leaves open whether screening or treatment alters NT-proBNP or outcomes.
Background: Depressive symptoms frequently occur in patients with heart failure (HF). However, research on the relationship between these symptoms and N-terminal pro-brain natriuretic peptide (NT-proBNP), a key biomarker for HF severity and treatment, is scarce and yields inconsistent results. Aims: This study investigates the relationship among depressive symptomatology, NT-proBNP and health status in a cohort of patients with HF. Additionally, it assesses the impact of depressive symptoms on their clinical outcomes. Methods: A cohort of 151 patients with HF was followed for 1 year. The Hospital Anxiety and Depression Scale-Depression (HADS-D) Score was used to assess anxiety and depressive symptoms, and NT-proBNP levels were measured. Health status was evaluated using the Kansas City Cardiomyopathy Questionnaire (KCCQ). Results: Patients with HADS-D scores>5 points showed significantly higher NT-proBNP levels and lower KCCQ scores at baseline. Over the year, changes in HADS-D scores correlated positively with changes in NT-proBNP levels and negatively with changes in KCCQ scores. A baseline HADS-D score>5 points was significantly associated with an increased risk of the composite outcome of all-cause mortality and HF hospitalisation, even after adjusting for baseline characteristics (adjusted hazard ratio (HR): 2.17; 95% CI 1.05 to 4.48; p=0.036). Conclusions: HADS-D scores are significantly correlated with NT-proBNP levels and health status in patients with HF. A baseline HADS-D score>5 points is significantly associated with an elevated risk for the composite outcome of all-cause mortality and hospitalisation due to HF.
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Balata et al. (2024) conducted a cohort in heart failure (n=151). Baseline HADS-D score > 5 points vs. Baseline HADS-D score ≤ 5 points was evaluated on composite outcome of all-cause mortality and HF hospitalisation (HR 2.17, 95% CI 1.05 to 4.48, p=0.036). A baseline HADS-D score >5 points was significantly associated with an increased risk of all-cause mortality and heart failure hospitalisation (adjusted HR 2.17; 95% CI 1.05 to 4.48; p=0.036).
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