Key result
A Gradient Boosting Machine model utilizing 4D flow parameters of the superior vena cava predicted cardiac remodeling and/or myocardial fibrosis in athletes with an AUC of 0.891 and 85.2% accuracy.
Why the study?
This study aimed to assess hemodynamic changes in the vena cava and predict cardiac remodeling and myocardial fibrosis in athletes using 4D flow parameters.
Can 4D flow hemodynamic parameters of the vena cava predict cardiac remodeling and/or myocardial fibrosis in athletes?
Cross-Sectional (n=137)
Can 4D flow hemodynamic parameters of the vena cava predict cardiac remodeling and/or myocardial fibrosis in athletes?
Effect estimate: AUC 0.891
Machine learning models utilizing 4D flow CMR parameters of the vena cava can effectively predict cardiac remodeling and myocardial fibrosis in athletes.
4D flow vena cava parameters may flag remodeling/fibrosis risk in athletes; leaves open validation and incremental utility over standard CMR.
PURPOSE: This study aimed to assess the hemodynamic changes in the vena cava and predict the likelihood of Cardiac Remodeling (CR) and Myocardial Fibrosis (MF) in athletes utilizing four-dimensional (4D) parameters. MATERIALS AND METHODS: A total of 108 athletes and 29 healthy sedentary controls were prospectively recruited and underwent Cardiac Magnetic Resonance (CMR) scanning. The 4D flow parameters, including both general and advanced parameters of four planes for the Superior Vena Cava (SVC) and Inferior Vena Cava (IVC) (sheets 1-4), were measured and compared between the different groups. Four machine learning models were employed to predict the occurrence of CR and/or MF. RESULTS: Most general 4D flow parameters related to VC were increased in athletes and positive athletes compared to controls (p < 0.05). Gradient Boosting Machine (GBM) was the most effective model in sheet 2 of SVC, with the area under the curve values of 0.891, accuracy of 85.2%, sensitivity of 84.6%, and specificity of 85.4%. The top five predictors in descending order were as follows: net positive volume, forward volume, waist circumference, body weight, and body surface area. CONCLUSION: Physical activity can induce a high flow state in the vena cava. CR and/or MF may elevate the peak velocity and maximum pressure gradient of the IVC. This study successfully constructed a GBM model with high efficacy for predicting CR and/or MF. This model may provide guidance on the frequency of follow-up and the development of appropriate exercise plans for athletes.
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Zhang et al. (2025) conducted a cross-sectional in Cardiac Remodeling and Myocardial Fibrosis (n=137). Physical activity vs. Healthy sedentary controls was evaluated on Prediction of Cardiac Remodeling (CR) and/or Myocardial Fibrosis (MF) (AUC 0.891). A Gradient Boosting Machine model utilizing 4D flow parameters of the superior vena cava predicted cardiac remodeling and/or myocardial fibrosis in athletes with an AUC of 0.891 and 85.2% accuracy.
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