Key result
A truncated form of the alpha 1 subunit of the cardiac voltage-gated calcium channel from murine erythroleukemia cells forms a functional channel when co-expressed in Xenopus oocytes.
Identifies and characterizes a novel truncated cardiac voltage-gated calcium channel expressed in non-excitable murine erythroleukemia cells that forms a functional channel.
No immediate clinical implications; leaves open the role of truncated CaV channels in cardiac and hematopoietic cells.
Calcium entry, via a dihydropyridine-sensitive pathway, is required for differentiation in murine erythroleukemia cells (MELC). Calcium channel currents have been identified physiologically in some non-excitable cells, but little is known regarding the structure of these channels. We show that a truncated form of the alpha 1 subunit of the cardiac voltage-gated calcium channel (dihydropyridine receptor, DHPR) is expressed in MELC. This MELC calcium channel lacks the first four transmembrane segments of the DHPR (IS1 to IS4). A MELC calcium channel/cardiac DHPR chimera, co-expressed with the alpha 2 and beta subunits of the DHPR, forms a functional calcium channel in Xenopus oocytes.
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Ma et al. (1995) studied this question. Co-expression of MELC calcium channel/cardiac DHPR chimera with alpha 2 and beta subunits was evaluated on Formation of a functional calcium channel in Xenopus oocytes. A truncated form of the alpha 1 subunit of the cardiac voltage-gated calcium channel from murine erythroleukemia cells forms a functional channel when co-expressed in Xenopus oocytes.
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