Smooth muscle and brain inositol 1,4,5-trisphosphate receptors are structurally and functionally similar.

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Population

Bovine smooth muscle and mouse brain tissue/receptors

Design

Preclinical

Authors

Discussion

Mouse data indicate InsP3 receptor homology but warrant no clinical change; leaves open functional identity in humans.

Population

Bovine smooth muscle and mouse brain tissue/receptors

Intervention

Direct comparison of InsP3 binding and primary structure

Outcome

KD for InsP3 binding and primary structure sequencesurrogate

Smooth muscle and brain InsP3 receptors are structurally and functionally similar, with identical cDNA sequences for the cloned portion.

Marks et al. (1990) studied this question.

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