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August 1, 1985Proceedings of the National Academy of SciencesOpen Access

Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle.

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Population

Rabbit main pulmonary artery smooth muscle permeabilized with saponin or digitonin

Design

Preclinical

Authors

ASAvril V. SomlyoVascular / Pulmonary VascularMBMeredith BondCleveland State UniversityASA P SomlyoUPMC Presbyterian

Discussion

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Implication

Does not support clinical use in vascular disorders; leaves open translation of InsP3 signaling to human pulmonary artery function.

Structured PICO

P
Population
Rabbit main pulmonary artery smooth muscle permeabilized with saponin or digitonin
I
Intervention
Inositol 1,4,5-trisphosphate (InsP3) (0.5-30 microM)
O
Outcome
Calcium release and tension development (contraction)surrogate

InsP3 acts as an intracellular messenger mediating calcium release from the sarcoplasmic reticulum and subsequent contraction in vascular smooth muscle.

Cite This Study

Somlyo et al. (1985) studied this question.

synapsesocial.com/papers/6a6fdc0778a11c550e09a345https://doi.org/10.1073/pnas.82.15.5231
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanisms of Ca2+ release from sarcoplasmic reticulum of skeletal muscle1984 · 329 citations
  2. 2Carbachol causes rapid phosphodiesteratic cleavage of phosphatidylinositol 4,5-bisphosphate and accumulation of inositol phosphates in rabbit iris smooth muscle; prazosin inhibits noradrenaline- and ionophore A23187-stimulated accumulation of inositol phosphates1984 · 98 citations
  3. 3SARCOPLASMIC RETICULUM AND EXCITATION-CONTRACTION COUPLING IN MAMMALIAN SMOOTH MUSCLES1972 · 530 citations