Key result
Inositol-1,4,5-trisphosphate transiently increased contractions at 1-10 microM and decreased them at 50-300 microM, but had no effect on L-type calcium current in guinea pig ventricular myocytes.
Population
Single guinea pig ventricular myocytes
Comparison
Intracellularly applied inositol-1,4,5-trisphosph… vs Cyclic AMP (cAMP) (10-300 microM) or baseline
Design
Preclinical
Authors
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InsP3 may enhance ventricular myocyte contraction independently of ICa(L); leaves open its role as muscarinic messenger.
Intracellular InsP3 modulates ventricular myocyte contractions but does not act as a messenger for stimulating L-type calcium current.
Tomoaki Saeki (1999) studied this question. Inositol-1,4,5-trisphosphate (InsP3) was evaluated on L-type calcium current (ICa(L)) and contractions. Inositol-1,4,5-trisphosphate transiently increased contractions at 1-10 microM and decreased them at 50-300 microM, but had no effect on L-type calcium current in guinea pig ventricular myocytes.
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