Key result
Inositol 1,4,5-trisphosphate (20 microM) and caffeine (20 mM) evoked tension increases to approximately 44% and 83% of maximum tension in permeabilized chick atrial muscle.
Population
Saponin-treated chick atrial muscle
Design
Preclinical
Authors
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Supports IP3 as Ca2+ mobilizer in avian atrium; leaves open relevance to mammalian or human myocardium.
Absolute Event Rate: 44% vs 100%
IP3 acts as a calcium-mobilizing messenger, releasing calcium from the sarcoplasmic reticulum to increase tension in atrial muscle.
Vites et al. (1990) studied this question. Inositol 1,4,5-trisphosphate (IP3) and caffeine vs. pCa 5.0 (maximum tension) was evaluated on Tension increase (contracture). Inositol 1,4,5-trisphosphate (20 microM) and caffeine (20 mM) evoked tension increases to approximately 44% and 83% of maximum tension in permeabilized chick atrial muscle.
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