Extent and Patterns of Adaptation of Enzyme Activities in Livers of Normal Rats Fed Diets High in Glucose and Fructose

This is the authors' abstract. We don't add key points for this paper.

Earlier reports (1,2) showed that the activities of four hepatic enzymes involved in the utilization of glucose 6-phosphate were altered, some of them dramatically, simply by substitution of diets rich in free hexoses (glucose or fructose) for a stock diet devoid of them. The adaptation by four enzymes led us to explore the extent and nature of the adjustment. We sought to learn whether it went beyond the enzymes concerned with the immediate fate of glucose g-phosphate and if so, whether it was patterned upon known changes in metabolism. In the present investigation we therefore studied the activities of a total of 17 enzymes that function in the Embden-Meyerhof and hexosemonophosphate oxidative pathways, the tricarboxylic acid cycle, and amino acid metabolism.