Key result
Direct inhibitors of thrombin and factor Xa attenuate clot-induced mitogenesis and inflammatory gene expression in human vascular smooth muscle cells.
Why the study?
Do direct inhibitors of thrombin and factor Xa attenuate clot-induced mitogenesis and inflammatory gene expression in human vascular smooth muscle cells?
Do direct inhibitors of thrombin and factor Xa attenuate clot-induced mitogenesis and inflammatory gene expression in human vascular smooth muscle cells?
Direct inhibitors of thrombin and factor Xa demonstrate anti-mitogenic and anti-inflammatory effects on human vascular smooth muscle cells in vitro.
Does not support altering antithrombotic regimens; leaves open in vivo relevance for vascular remodeling.
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Rosenkranz et al. (2011) studied this question. Direct inhibitors of thrombin and factor Xa attenuate clot-induced mitogenesis and inflammatory gene expression in human vascular smooth muscle cells.
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