What question did this study set out to answer?

To construct a biosafe, all-in-one nanotheranostic platform integrating trimodal imaging with combined photothermal therapy and chemotherapy for cancer treatment.

December 3, 2014Advanced Healthcare Materials

Facile Preparation of Doxorubicin‐Loaded Upconversion@Polydopamine Nanoplatforms for Simultaneous In Vivo Multimodality Imaging and Chemophotothermal Synergistic Therapy

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Authors

FLFuyao Liu XHXiuxia He ZLZhen Lei

Discussion

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Overview

Preclinical study demonstrates complete tumor eradication in mice, indicating the therapeutic promise of a multifunctional nanoplatform combining trimodal imaging with chemophotothermal therapy.

Key Points

To construct a biosafe, all-in-one nanotheranostic platform integrating trimodal imaging with combined photothermal therapy and chemotherapy for cancer treatment.
Coated oleic-acid-capped β-NaGdF4:Yb(3+),Er(3+)@β-NaGdF4 upconverting nanoparticle cores with a near-infrared-absorbing polydopamine shell using a water-in-oil microemulsion method, followed by PEGylation and doxorubicin loading.
Evaluated trimodal imaging (upconversion luminescence, T1-weighted MRI, and X-ray CT), chemophotothermal efficacy under 808 nm laser irradiation in SW620 tumor-bearing mice, and systemic toxicity through histology and blood biochemistry.
Application of 808 nm near-infrared laser irradiation with the nanoplatform produced synergistic chemophotothermal cytotoxicity that completely eradicated SW620 tumors in mice without recurrence.
In vitro and in vivo safety assays, including hemolysis, leakage, organ histology, and blood biochemistry, showed negligible cytotoxicity and organ toxicity.

Cite This Study

Liu et al. (2014) studied this question.

synapsesocial.com/papers/6a93e6831e998d99dafece0b https://doi.org/10.1002/adhm.201400676

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December 3, 2014Advanced Healthcare Materials

Facile Preparation of Doxorubicin‐Loaded Upconversion@Polydopamine Nanoplatforms for Simultaneous In Vivo Multimodality Imaging and Chemophotothermal Synergistic Therapy

View Full Paper

Ask AI

Bookmark

Authors

FLFuyao Liu XHXiuxia He ZLZhen Lei

Discussion

Member takes

Overview

Preclinical study demonstrates complete tumor eradication in mice, indicating the therapeutic promise of a multifunctional nanoplatform combining trimodal imaging with chemophotothermal therapy.

Key Points

To construct a biosafe, all-in-one nanotheranostic platform integrating trimodal imaging with combined photothermal therapy and chemotherapy for cancer treatment.
Coated oleic-acid-capped β-NaGdF4:Yb(3+),Er(3+)@β-NaGdF4 upconverting nanoparticle cores with a near-infrared-absorbing polydopamine shell using a water-in-oil microemulsion method, followed by PEGylation and doxorubicin loading.
Evaluated trimodal imaging (upconversion luminescence, T1-weighted MRI, and X-ray CT), chemophotothermal efficacy under 808 nm laser irradiation in SW620 tumor-bearing mice, and systemic toxicity through histology and blood biochemistry.
Application of 808 nm near-infrared laser irradiation with the nanoplatform produced synergistic chemophotothermal cytotoxicity that completely eradicated SW620 tumors in mice without recurrence.
In vitro and in vivo safety assays, including hemolysis, leakage, organ histology, and blood biochemistry, showed negligible cytotoxicity and organ toxicity.

Cite This Study

Liu et al. (2014) studied this question.

synapsesocial.com/papers/6a93e6831e998d99dafece0b https://doi.org/10.1002/adhm.201400676

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