Key result
Extracellular matrix-derived peptides targeted to the myocardial infarct site induced angiogenesis and altered negative remodeling in a rodent model of ischemia/reperfusion myocardial infarction.
Why the study?
Do extracellular matrix-derived peptides induce angiogenesis and alter negative remodeling in a rodent model of myocardial infarction?
Do extracellular matrix-derived peptides induce angiogenesis and alter negative remodeling in a rodent model of myocardial infarction?
Extracellular matrix-derived peptides may offer a new strategy for repairing damaged myocardial tissue by inducing angiogenesis and altering negative remodeling.
Hypothesis-generating for targeted ECM peptides in rodent MI; human translation requires prospective validation.
Repairing cardiac tissue remains one of the most challenging goals in tissue engineering. Here, we discuss ways whereby we sought to treat myocardial infarctions using extracellular-matrix derived peptides. Using an ischemia/reperfusion myocardial infarction rodent model, we targeted these extracellular matrix-derived peptides to the myocardial infarct site and were able to induce angiogenesis and alter the negative remodeling seen after an acute myocardial infarction. Our results indicate a potentially new strategy for repairing damaged tissue.
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Mihardja et al. (2011) studied Myocardial infarction. Extracellular matrix-derived peptides was evaluated on Angiogenesis and negative remodeling. Extracellular matrix-derived peptides targeted to the myocardial infarct site induced angiogenesis and altered negative remodeling in a rodent model of ischemia/reperfusion myocardial infarction.
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