Key result
Neither 17 alpha-oestradiol nor 17 beta-oestradiol had any effect on the secreted inhibin level in either the presence or absence of FSH in rat Sertoli cells.
Why the study?
Do 17 alpha-oestradiol and 17 beta-oestradiol affect basal and FSH-stimulated inhibin B secretion in rat Sertoli cells?
Do 17 alpha-oestradiol and 17 beta-oestradiol affect basal and FSH-stimulated inhibin B secretion in rat Sertoli cells?
17 alpha-oestradiol and 17 beta-oestradiol do not play an essential role in regulatory processes involving inhibin or FSH in rat Sertoli cells.
Answers are grounded in this paper and cite their sources.
No effect of either oestradiol on inhibin in rat Sertoli cells; leaves open any in vivo or human regulatory role.
The effects of 17 alpha-oestradiol and 17 beta-oestradiol on basal and follicle-stimulating hormone (FSH)-stimulated inhibin B secretion by rat Sertoli cells were studied. Sertoli cells were isolated and cultivated from testes of 18-day-old Wistar rats in the presence and absence of FSH and different doses of oestrogens. On day 4 of culture, secreted inhibin was measured by enzyme-linked immunosorbent assay. Neither 17 alpha-oestradiol nor 17 beta-oestradiol had any effect on the secreted inhibin level in either the presence or absence of FSH. It is concluded that these oestradiols do not play an essential role in regulatory processes involving inhibin or FSH.
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Berlau et al. (2000) studied this question. 17 alpha-oestradiol and 17 beta-oestradiol vs. absence of oestrogens was evaluated on basal and FSH-stimulated inhibin B secretion. Neither 17 alpha-oestradiol nor 17 beta-oestradiol had any effect on the secreted inhibin level in either the presence or absence of FSH in rat Sertoli cells.
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