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October 1, 1990Archives of Disease in ChildhoodOpen Access

Amniotic fluid insulin concentration as a predictor of obesity.

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Authors

BMBoyd E. MetzgerNorthwestern UniversityBSBernard L. SilvermanOffice of Chief Medical ExaminerNFNorbert FreinkelBoston University

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Implication

Prospective study reveals fetal insulin exposure correlates with relative obesity in children of diabetic mothers, suggesting intrauterine metabolism programs long-term weight development.

Key Points

  • To determine whether late-gestational amniotic fluid insulin concentration predicts the risk of childhood obesity in offspring of diabetic mothers.
  • Conducted a prospective longitudinal cohort evaluation of 56 children of diabetic mothers.
  • Measured amniotic fluid insulin concentration between 32 and 38 weeks of gestation and recorded anthropometric measurements at birth and at 6 years of age.
  • Performed correlation analyses adjusting for maternal obesity and neonatal macrosomia.
  • Amniotic fluid insulin concentrations significantly correlated with relative obesity at 6 years of age, maintaining significance after adjusting for maternal obesity and birth macrosomia.
  • The highest intrauterine insulin values clustered specifically within the subgroup of 14 children who developed overt obesity by age 6.

Cite This Study

Metzger et al. (1990) studied this question.

synapsesocial.com/papers/6a93e82fd62c45db251d3891https://doi.org/10.1136/adc.65.10_spec_no.1050
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Excessive Obesity in Offspring of Pima Indian Women with Diabetes during Pregnancy1983 · 541 citations
  2. 2Gestational Diabetes Mellitus: Heterogeneity of Maternal Age, Weight, Insulin Secretion, HLA Antigens, and Islet Cell Antibodies and the Impact of Maternal Metabolism on Pancreatic B-Cell and Somatic Development in the Offspring1985 · 214 citations
  3. 3Human Fetal Insulin Metabolism Early in Gestation: Response to Acute Elevation of the Fetal Glucose Concentration and Placental Transfer of Human Insulin-I-1311969 · 156 citations
  4. 4WEIGHT AND LENGTH AT BIRTH OF INFANTS OF DIABETIC MOTHERS1954 · 496 citations
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