Key result
Computational analysis demonstrated that the proposed multi-epitope vaccine against Enterovirus 71 is potentially safe, non-allergenic, and capable of eliciting a strong immune response in silico.
Why the study?
Despite the significant burden of Enterovirus 71-induced hand-foot and mouth disease, no authorized vaccine is available, and previously identified attenuated or inactivated vaccines become ineffective over time due to viral genome changes.
Does a computationally designed multi-epitope vaccine against enterovirus 71 elicit an immune response in silico?
Does a computationally designed multi-epitope vaccine against enterovirus 71 elicit an immune response in silico?
Computational analysis suggests the proposed multi-epitope vaccine against enterovirus 71 is potentially safe and immunogenic, warranting further in vitro and in vivo validation.
EV71 vaccine gap persists for Asian pediatric HFMD; novel Level 5 human data leaves open durable candidates.
Purpose: Enterovirus 71, a pathogen that causes hand-foot and mouth disease (HFMD) is currently regarded as an increasing neurotropic virus in Asia and can cause severe complications in pediatric patients with blister-like sores or rashes on the hand, feet, and mouth.Notwithstanding the significant burden of the disease, no authorized vaccine is available.Previously identified attenuated and inactivated vaccines are worthless over time owing to changes in the viral genome.Materials and Methods: A novel vaccine construct using B-cell derived T-cell epitopes from the virulent polyprotein found the induction of possible immune response.In order to boost the immune system, a beta-defensin 1 preproprotein adjuvant with EAAAK linker was added at the N-terminal end of the vaccine sequence.Results: The immunogenicity of the designed, refined, and verified prospective threedimensional-structure of the multi-epitope vaccine was found to be quite high, exhibiting nonallergenic and antigenic properties.The vaccine candidates bound to toll-like receptor 3 in a molecular docking analysis, and the efficacy of the potential vaccine to generate a strong immune response was assessed through in silico immunological simulation.Conclusion: Computational analysis has shown that the proposed multi-epitope vaccine is possibly safe for use in humans and can elicit an immune response.
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Swain et al. (2024) studied Enterovirus 71 infection (Hand-foot and mouth disease). Multi-epitope vaccine candidate against Enterovirus 71 was evaluated on In silico immunogenicity, antigenicity, and safety. Computational analysis demonstrated that the proposed multi-epitope vaccine against Enterovirus 71 is potentially safe, non-allergenic, and capable of eliciting a strong immune response in silico.
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