Why the study?
Pericardial effusion and hemodynamically significant cardiac tamponade are exceedingly uncommon as the initial presentation of Hodgkin's lymphoma.
Case Report (n=1)
Cardiac tamponade can be an extremely rare initial presentation of Hodgkin's lymphoma.
Consider HL in unexplained tamponade; case report extends rare-presentation literature but leaves incidence and management open.
Hodgkin's lymphoma (HL) is a lymphoid neoplasm in which malignant Hodgkin or Reed-Sternberg cells are present in tissues mixed with heterogeneous non-malignant inflammatory cells. Pericardial effusion (PEEF) in HL is rare. Furthermore, hemodynamically significant effusions causing cardiac tamponade (CTp) are exceedingly uncommon. CTp as the initial presentation of HL is extremely rare. We describe the case of a 21-year-old man who presented with CTp requiring pericardiocentesis. On further workup, he was found to have a large mediastinal mass with a biopsy consistent with classic HL. His clinical course was complicated by the development of immune thrombocytopenia (ITP) and post-traumatic stress disorder (PTSD).
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Azanza et al. (2021) conducted a case report in Hodgkin's lymphoma (n=1). Multidisciplinary therapy including nivolumab was evaluated.
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