Myosin Heavy-Chain-Associated RNA Transcript for Cardiopulmonary Recovery Prediction in High-Intensity Interval Training for Coronary Artery Disease

This study highlights the expression characteristics of MHRT in CAD and analyzes its predictive potential regarding HIIT intervention on cardiopulmonary function and quality of life in CAD patients. A total of 88 CAD patients were enrolled, and non-CAD volunteers were randomly recruited as the study sample. Serum levels of MHRT were assessed by qRT-PCR. The association between MHRT levels and the Gensini score was assessed using Pearson's correlation analysis. The predictive value of MHRT in CAD was evaluated using ROC curves and logistic regression. Serum MHRT expression was elevated in CAD and correlated positively with the Gensini score. Cardiopulmonary function indicators and quality-of-life scores increased after the HIIT intervention in the HIIT group. Furthermore, serum MHRT decreased after the HIIT intervention, and levels were lower in the clinically effective group than in the ineffective group. HIIT significantly improved cardiopulmonary function and quality of life in CAD patients, accompanied by a marked reduction in serum MHRT levels. This suggests that MHRT may serve as a potential biomarker for monitoring HIIT efficacy.