High-dose vs. standard-dose influenza vaccine in heart failure: the FLUNITY-HD trial
Niklas Dyrby JohansenDaniel ModinJacobo Pardo‐SecoCarmen Rodríguez-Tenreiro-SánchezMatthew M. LoiaconoRebecca C. HarrisYoujun HuangRobertus van AalstAyman ChitCarsten Schade LarsenLykke LarsenLothar WieseMichael Dalager‐PedersenBrian L. ClaggettKira Hyldekær JanstrupCarmen Duran-ParrondoMarta Piñeiro-SoteloMartín Cribeiro-GonzálezMónica Conde-PájaroSusana Mirás-CarballalJuan-Manuel González-PérezScott D. SolomonPradeesh SivapalanCyril Jean‐Marie MartelJens‐Ulrik Stæhr JensenFederico Martinón‐TorresTor Biering‐Sørensenthe GALFLU Trial Team for the DANFLU-2 Study Group and SkaarupKatja Vu BartholdyKatrine Feldballe BernholmJulie Inge-Marie Helene BorchseniusFilip Soeskov DavidovskiLise Witten DavodianMaria DonsLisa Steen DuusCaroline EspersenFrederik Holme FussingAnne Marie Reimer JensenNino Emanuel LandlerAdam Cadovius Femerling LanghoffMats Christian Højbjerg LassenAnne Bjerg NielsenCamilla Ikast OttosenMorten SengeløvKristoffer GrundtvigAna Maria Abal SeninPilar Alonso VenceRosa María Álvarez GilTalía Álvarez SuárezLidia Alvarez DapiaJose Manuel Alvarez PenaSilvia Amoedo CasqueiroPatricia Aran AbelendaJosefa Araujo RodriguezAna Ares MartínezMaria Asensio NietoNoelia Belen Ayllon MorcilloMónica Barral CarregalMaria Begoña Baquero SabajanesAlejandro Baña ToméLorena Bayon DizDamian Bernardez SendeBeatriz Blanco SalgadoLucia Bruquet CostaFaustino Caballero MuineloNoelia Cabeiras AlvarezMaria Montserrat Estevez FernandezAlba Campero OjeaIsabel Campos PardoDiego Canedo CoteloLidia Carreira DiazMiguel Angel Carreiro AlonsoAlmudena Carro OrgeiraAdriAna Maria Castelo TriñanesAna Belen Castelo VazquezCésar Castro PitaAndrea Castro SandeManuel Castro GuizanMercedes Castro BacarizaMaria Jose Castro CastroMaria Jose Castroman SoutoSabela Ceide FernandezOlga María Ces OzoresRebeca Chouza AlonsoVerónica Civeira PérezCarla Alexandra Correia Parautaana isabel corbal obelleiroAngela Coutado BelonXurxo Couto CatoiraAna Isabel Couto TobíoEvaristo Cuerdo CotonAngeles Cuiña CanedaSonia De Miguel CañasPaola De Castro GarciaMaria Eugenia De Jesús Torrealba ValenteCarmen Del Ojo PaezMaría Begoña Del Oro SaezRomina Deus SuarezPaula Diaz LópezLucia Diaz Gonzalez
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“The results suggest additional effectiveness with HD-IIV compared with SD-IIV against cardiovascular outcomes but should be interpreted as exploratory findings in the setting of a large randomized clinical trial with a neutral primary outcome.”
“The 6.3% reduction in cardio-respiratory hospitalisations with HD-IIV versus SD-IIV represents a clinically meaningful finding with important implications for cardiovascular preventive care, warranting consideration in clinical practice guidelines.”
“Although the observed absolute differences in outcomes may seem small, they could still represent a potentially meaningful clinical benefit.”
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Johansen et al. (2026) studied this question.