Key result
Standardization of D-dimer reporting is needed to address inconsistent units and thresholds, with a potential method recently described to generate a stable standard material.
Highlights the need for standardization of D-dimer reporting, especially given its increased use for thrombosis management during the COVID-19 pandemic.
D‐dimer test, one of the most common tests for coagulation, plays an important role in management of patients with thrombosis, and its demand has risen sharply during the current global COVID‐19 epidemic. However, some main limitations, including inconsistent reporting units, various thresholds for different assays, lack of standardization, and poor harmonization,1 have followed its widespread application and may cause confusion and misinformation.2 Recently, a communication from the ISTH Scientific and Standardization Subcommittee (SSC) on Fibrinolysis reported by Bevan and Longstaff described a potential method to generate a stable standard material for D‐dimer.
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Zhang et al. (2022) conducted an editorial in COVID-19 and thrombosis. D-dimer standardization was evaluated. Standardization of D-dimer reporting is needed to address inconsistent units and thresholds, with a potential method recently described to generate a stable standard material.
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