Key result
Hydroxocobalamin administration in 24 post-cardiopulmonary bypass patients was associated with favorable changes in hemodynamic parameters and vasopressor requirements.
Why the study?
Does hydroxocobalamin improve hemodynamic variables and reduce vasopressor requirements in post-cardiopulmonary bypass patients with suspected vasoplegic syndrome?
Observational (n=24)
Does hydroxocobalamin improve hemodynamic variables and reduce vasopressor requirements in post-cardiopulmonary bypass patients with suspected vasoplegic syndrome?
Hydroxocobalamin administration in post-cardiopulmonary bypass patients with suspected vasoplegic syndrome is associated with favorable changes in hemodynamics and reduced vasopressor requirements.
May support rescue hydroxocobalamin in post-CPB vasoplegia; hypothesis-generating without randomized confirmation.
Hydroxocobalamin (vitamin B12a) is an emerging treatment for vasoplegic syndrome (VS) associated with cardiopulmonary bypass (CPB). Given its cost and scarcity, an institutional guideline for its use as a rescue treatment in cases of suspected VS was developed. Hemodynamic variables and vasopressor requirements were reviewed for a series of 24 post-CPB patients who received B12a. Favorable changes in hemodynamic parameters and vasopressor requirements were seen after B12a administration although guideline criteria for VS were inconsistently met. These findings support the continued study of B12a in patients with CPB-associated VS.
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Armour et al. (2018) conducted an observational in Vasopressor refractory hypotension after cardiopulmonary bypass (n=24). Hydroxocobalamin (Vitamin B12a) was evaluated on Hemodynamic variables and vasopressor requirements. Hydroxocobalamin administration in 24 post-cardiopulmonary bypass patients was associated with favorable changes in hemodynamic parameters and vasopressor requirements.
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