Key result
A non-diabetic patient experienced an unusual, life-threatening immunologic reaction to protamine sulfate, including clotting of anastomosis sites, following an uneventful off-pump CABG.
Case Report (n=1)
Highlights a rare but life-threatening immunologic reaction to protamine sulfate involving clotting of anastomosis sites after off-pump CABG in a non-diabetic patient.
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Rare protamine reaction with clotting warrants vigilance post-CABG; case reports leave open incidence and prevention strategies.
Immunologic reactions to protamine sulphate during cardiac surgery are very rare. The frequency and outcome of such adverse reaction is unclear. Clotting of distal anastomosis sites and proximal site (in aorta) is very rare. We report a case of unusual life-threatening reaction to protamine that occurred in a non-diabetic patient following the uneventful off pump coronary artery bypass grafting operation.
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Mohanty et al. (2017) conducted a case report in Protamine reaction after off-pump CABG (n=1). Protamine sulphate was evaluated on Life-threatening immunologic reaction (clotting of anastomosis sites). A non-diabetic patient experienced an unusual, life-threatening immunologic reaction to protamine sulfate, including clotting of anastomosis sites, following an uneventful off-pump CABG.
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