What does this research mean for the field?

The targeted 2024-25 RSV immunization program in Québec reduced RSV-associated hospitalizations by nearly 50% among adults aged ≥75 years residing in private senior residences, though the population-level impact was lower. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the real-world population impact of the 2024–2025 RSV immunization program on hospitalizations among older adults in Québec while adjusting for diagnostic test performance.

August 30, 2026Archives of Public HealthOpen Access

Impact of respiratory syncytial virus immunization in older adults: the importance of a valid burden estimation

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Authors

CGCharles-Antoine GuayUniversité de Sherbrooke RDRadhouene DogguiInstitut National de Santé Publique du Québec ÉFÉlise FortinÉcole Nationale d'Administration Publique

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Implication

Ecological study reveals a 49% reduction in RSV hospitalizations among targeted residence seniors, highlighting the population-level benefit of targeted immunization.

Key Points

To evaluate the real-world population impact of the 2024–2025 RSV immunization program on hospitalizations among older adults in Québec while adjusting for diagnostic test performance.
Analyzed data from prospective hospital-based surveillance (HospiVir) and health administrative databases covering seniors residing in long-term care and private senior residences (PSR, age ≥75) with ~65% vaccine uptake.
Employed an observed-to-expected approach and a before-and-after ecological design using difference-in-difference Poisson regression to account for seasonal variations.
Adjusted hospitalization incidence rate estimates for laboratory diagnostic test performance using Lash equations.
RSV-associated hospitalizations decreased by 49% (95% CI: -80% to -5%) among adults aged ≥75 residing in private senior residences based on surveillance data.
Surveillance data showed a 23% reduction (95% CI: -38% to 66%) in RSV hospitalizations across the overall population aged ≥75, while administrative data showed a non-significant 10% reduction (95% CI: -7% to 23%).
Adjusting for diagnostic test performance changed the estimated absolute disease burden based on test positivity but did not alter the measured relative impact of the immunization program.

Cite This Study

Guay et al. (2026) studied this question.

synapsesocial.com/papers/6a93efc06c1a8fb52e79bd0c https://doi.org/10.1186/s13690-026-02054-3

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Implication

Ecological study reveals a 49% reduction in RSV hospitalizations among targeted residence seniors, highlighting the population-level benefit of targeted immunization.

Impact of respiratory syncytial virus immunization in older adults: the importance of a valid burden estimation

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of respiratory syncytial virus immunization in older adults: the importance of a valid burden estimation

Discussion

Member takes

Implication

Key Points

Cite This Study

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