Key result
Elevated urinary MMP-9 in diabetic kidney disease correlates with increased proteinuria and pulse wave velocity.
Why the study?
MMP-9 influences extracellular matrix remodeling, inflammation, and renal hemodynamics in kidney diseases, motivating investigation into its relationship with proteinuria and pulse wave velocity in DKD.
Population
67 patients with DKD and 21 healthy controls
Comparison
Patients with DKD vs healthy controls
Design
Cross-sectional study
Authors
Loading...
Urinary MMP-9 associates with proteinuria and PWV in DKD; leaves open biomarker or therapeutic relevance pending prospective validation.
Cross-Sectional (n=88)
No
Effect estimate: r = 0.360
p-value: p=0.003
Urinary MMP-9 is independently associated with proteinuria and correlates with pulse wave velocity, suggesting it may serve as a biomarker for both renal dysfunction and systemic vascular complications in diabetic kidney disease.
ERÇİN et al. (2026) conducted a cross-sectional in Diabetic kidney disease (n=88). Urinary MMP-9 vs. Healthy controls was evaluated on Correlation between urinary MMP-9 and proteinuria (r = 0.360, p=0.003). Urinary MMP-9 levels were significantly elevated in patients with diabetic kidney disease and positively correlated with proteinuria (r=0.360, p=0.003) and pulse wave velocity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: