Key result
Tilt testing combined with lower body negative pressure provides a highly reproducible measure of orthostatic tolerance, yielding a specificity of 92% and sensitivity of 85% for discriminating patients with syncope from healthy controls.
Why the study?
Does passive tilt testing combined with lower body negative pressure improve the diagnosis of orthostatic intolerance compared to passive tilt alone or with pharmacological provocation in patients with syncope?
Population
Patients with orthostatic intolerance or syncope of unknown cause, and healthy control subjects
Comparison
Passive tilt testing combined with lower body… vs Passive tilt alone or passive tilt with…
Design
Review
Authors
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May support non-pharmacological orthostatic assessment in syncope; leaves open prospective validation versus standard tilt protocols.
Does passive tilt testing combined with lower body negative pressure improve the diagnosis of orthostatic intolerance compared to passive tilt alone or with pharmacological provocation in patients with syncope?
Combining passive tilt testing with lower body negative pressure provides a highly sensitive and specific method for assessing orthostatic tolerance without the need for invasive procedures or pharmacological provocation.
Protheroe et al. (2013) studied Orthostatic intolerance / Syncope (n=63). Tilt Testing with Combined Lower Body Negative Pressure was evaluated on Time to presyncope (orthostatic tolerance). Tilt testing combined with lower body negative pressure provides a highly reproducible measure of orthostatic tolerance, yielding a specificity of 92% and sensitivity of 85% for discriminating patients with syncope from healthy controls.