Intestinal Metaplasia of the Distal Esophagus in a Patient With Untreated Achalasia—An Unusual Case and Review of Literature

Q: What does this research mean for the field?

Barrett's esophagus and achalasia can rarely coexist in the same patient despite having opposing pathophysiologic mechanisms. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Rohan Karkra; Mahinaz Mohsen; Salil Chowdhury; Kaveh Hajifathalian; Ahmed Al‐Khazraji

doi:10.1002/ccr3.73394

August 27, 2026Clinical Case ReportsOpen Access

Intestinal Metaplasia of the Distal Esophagus in a Patient With Untreated Achalasia—An Unusual Case and Review of Literature

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Key Points

Document a rare clinical presentation of intestinal metaplasia occurring in a patient with untreated achalasia and evaluate the literature on these opposing pathophysiologic conditions.
Evaluated a 51-year-old female presenting with an 8-month history of progressive dysphagia, postprandial vomiting, and significant weight loss.
Reviewed relevant literature regarding the diagnostic and pathophysiologic overlap of achalasia and Barrett's esophagus.
Demonstrated distal esophageal intestinal metaplasia despite untreated achalasia, an exceptionally rare occurrence given their opposing sphincter dynamics.
Identified prominent clinical manifestations driven by esophageal dysmotility, including progressive dysphagia and severe postprandial regurgitation.

Implication

Case report reveals intestinal metaplasia in an untreated achalasia patient, highlighting an unusual coexistence of opposing esophageal disorders.

Abstract

Barrett's esophagus (BE) and achalasia are distinct esophageal disorders with opposing pathophysiologic mechanisms, making their coexistence exceedingly rare. We describe a 51-year-old woman who presented with progressive dysphagia, postprandial vomiting, and significant weight loss over 8 months.

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Cite This Study

Karkra et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0476c1a8fb52e79c455 https://doi.org/10.1002/ccr3.73394

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Intestinal Metaplasia of the Distal Esophagus in a Patient With Untreated Achalasia—An Unusual Case and Review of Literature

Key Points

Implication

Abstract

Discussion

Cite This Study

Intestinal Metaplasia of the Distal Esophagus in a Patient With Untreated Achalasia—An Unusual Case and Review of Literature

Key Points

Implication

Abstract

Discussion

Cite This Study

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