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August 30, 2026MicrobiomeOpen Access

Baseline gut microbiome and metabolome profiles predict weight loss after a structured lifestyle intervention

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Authors

BSBenjamin SeethalerMBMaryam BasraiNDNathalie M. Delzenne

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Overview

Randomized trial reveals baseline gut microbial and metabolomic profiles predict dietary weight loss in adults with obesity, highlighting targets for personalized weight management.

Key Points

  • To determine whether baseline gut microbiome composition and serum metabolomic profiles can predict weight-loss success and metabolic improvements following a one-year structured dietary intervention.
  • Enrolled 50 adults with obesity (mean BMI 42 ± 7.0 kg/m²) in a one-year structured lifestyle intervention (ClinicalTrials.gov: NCT01344525).
  • Administered a three-phase dietary regimen: a 3-month formula diet (~850 kcal/day), a 3-month transition phase (~1000 kcal/day), and a 6-month maintenance phase (up to 2000 kcal/day).
  • Profiled clinical parameters, gut microbiota, and serum metabolomics longitudinally, utilizing random forest models to predict postintervention outcomes from baseline features.
  • The one-year intervention produced significant overall reductions in body weight, body fat percentage, C-reactive protein, and glycated hemoglobin.
  • Increased abundance of Lachnospiraceae correlated with enhanced gut barrier function, a relationship mediated by higher fecal butyrate and propionate levels.
  • Baseline serum levels of diacylphosphatidylcholine C40:1 predicted postintervention BMI, and multimodal random forest modeling accurately forecasted individual weight loss and clinical improvements.

Cite This Study

Seethaler et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0476c1a8fb52e79c548https://doi.org/10.1186/s40168-026-02501-x
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Also Consider

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  4. 4Abstract WE514: Changes in epigenomics and metabolomics biomarkers after a lifestyle intervention with diet and physical activity for weight loss in high cardiovascular risk individuals2026
  5. 5Genomic Study of Intestinal Microbiota: Assessing the Impact of Probiotics and Healthy Lifestyle on Weight Loss in Adults with Obesity2024 · 2 citations