Key result
A normal waist-to-height ratio of 0.49-0.59 was positively associated with a favourable neurological outcome (OR 3.45) following in-hospital cardiac arrest, indicating that central obesity worsens outcomes.
Why the study?
To investigate the association between central obesity and outcomes following in-hospital cardiac arrest.
Is central obesity associated with worse neurological outcomes in adult patients following in-hospital cardiac arrest?
Cohort (n=648)
No
Is central obesity associated with worse neurological outcomes in adult patients following in-hospital cardiac arrest?
Odds Ratio: 3.45 (95% CI 1.56–7.65)
p-value: p=0.002
Central obesity is associated with poorer neurological outcomes following in-hospital cardiac arrest, independent of overall BMI.
May support central adiposity measures for post-arrest risk stratification; leaves open prospective validation and independence from BMI.
To investigate the association between central obesity and outcomes following in-hospital cardiac arrest (IHCA). A single-centred retrospective study was conducted. Adult patients that experienced IHCA during 2006–2015 were screened. Body mass index (BMI) was calculated at hospital admission. Central obesity-related anthropometric parameters were measured by analysing computed tomography images. A total of 648 patients were included, with mean BMI of 23.0 kg/m2. The proportions of BMI-defined obesity in this cohort were underweight (13.1%), normal weight (41.4%), overweight (31.5%) and obesity (14.0%). The mean waist circumference was 85.9 cm with mean waist-to-height ratio (WHtR) of 0.53. The mean sagittal abdominal diameter was 21.2 cm with mean anterior and posterior abdominal subcutaneous adipose tissue (SAT) depths of 1.6 and 2.0 cm, respectively. Multivariate logistic regression analyses indicated BMI of 11.7–23.3 kg/m2 (odds ratio [OR]: 2.53, 95% confidence interval [CI]: 1.10–5.85; p-value = 0.03), WHtR of 0.49–0.59 (OR: 3.45, 95% CI: 1.56–7.65; p-value = 0.002) and anterior abdominal SAT depth <1.9 cm (OR: 2.84, 95% CI: 1.05–7.74; p-value = 0.04) were positively associated with the favourable neurological outcome. Central obesity was associated with poor IHCA outcomes, after adjusting for the effects of BMI.
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Wang et al. (2020) conducted a cohort in In-hospital cardiac arrest (IHCA) (n=648). Central obesity (measured by waist-to-height ratio) vs. Normal waist-to-height ratio (0.49-0.59) was evaluated on Favourable neurological status at hospital discharge (Cerebral Performance Category score 1 or 2) (OR 3.45, 95% CI 1.56-7.65, p=0.002). A normal waist-to-height ratio of 0.49-0.59 was positively associated with a favourable neurological outcome (OR 3.45) following in-hospital cardiac arrest, indicating that central obesity worsens outcomes.
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