Traditional Chinese Herbal Formula YA3D3 Ameliorates Alzheimer's Disease-Like Pathology and Cognitive Impairment in APP/PS1 Transgenic Mice.

Q: What does this research mean for the field?

The traditional Chinese herbal formula YA3D3 ameliorates Alzheimer's disease-like pathology and cognitive impairment in APP/PS1 transgenic mice, which is associated with the up-regulation of autophagy-related molecules such as ATG14. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Tian Yang; Jia-Rui Ma; Si-Yao Liang; Zhang Yue-meng; Ling Guo; Wu-Juan Li; Yu-Hong Lu

doi:10.3881/j.issn.1000-503x.17127

August 30, 2026

Traditional Chinese Herbal Formula YA3D3 Ameliorates Alzheimer's Disease-Like Pathology and Cognitive Impairment in APP/PS1 Transgenic Mice.

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Key Points

To evaluate the therapeutic efficacy of the traditional Chinese herbal formula YA3D3 on Alzheimer's disease-like pathology and cognitive impairment, specifically examining its influence on autophagy regulation.
Administered the herbal formula YA3D3 to an APP/PS1 transgenic mouse model of Alzheimer's disease.
Assessed cognitive performance, pathological markers, and the expression levels of autophagy-associated regulatory molecules, including ATG14.
YA3D3 treatment ameliorated Alzheimer's disease-like pathology and cognitive impairment in APP/PS1 mice.
Treatment induced the up-regulation of the autophagy-related marker ATG14 and regulated related molecular expression, though functional enhancement of autophagy flux was not confirmed.

Implication

Animal study reveals herbal formula YA3D3 alters autophagy-related proteins in APP/PS1 mice, indicating potential therapeutic value against Alzheimer disease pathology.

Abstract

therapeutic efficacy of YA3D3 and the up-regulation of ATG14 requires further confirmation.In addition，this study only verifies the expression regulation of autophagy-related molecules and does not confirm the enhancement of autophagy flux.

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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a93f07a6c1a8fb52e79c9fa https://doi.org/10.3881/j.issn.1000-503x.17127

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Traditional Chinese Herbal Formula YA3D3 Ameliorates Alzheimer's Disease-Like Pathology and Cognitive Impairment in APP/PS1 Transgenic Mice.

Key Points

Implication

Abstract

Discussion

Cite This Study

Traditional Chinese Herbal Formula YA3D3 Ameliorates Alzheimer's Disease-Like Pathology and Cognitive Impairment in APP/PS1 Transgenic Mice.

Key Points

Implication

Abstract

Discussion

Cite This Study

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